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Pharmaceutical Chemistry
L-Histidine
Formula:
C₆H₉N₃O₂
GOST/CAS:
CAS 71-00-1
L-Histidine (highly purified essential amino acid, pharmacopoeia quality) is a white crystalline powder that serves as a vital structural block in the production of pharmaceuticals, infusion solutions, and specialized nutrition. This product is actively involved in the synthesis of proteins, hemoglobin, carnosine, and histamine, and effectively regulates metabolic processes. Due to strict impurity control and full compliance with international pharmaceutical standards (USP/EP/BP), this L-Histidine is indispensable in the pharmaceutical industry, dietary supplement (supplement) manufacturing, and biotechnology.
Applications
Infusion Solutions Production: Used as a baseline component in the preparation of complex solutions for parenteral (intravenous) nutrition. It ensures nitrogen balance and supports protein metabolism in recovering patients.
Pharmaceuticals and Supplements: Included in the formulation of cardioprotective, anti-ulcer, and immunomodulating drugs. It is widely used in manufacturing targeted amino acid complexes to support joints, muscles, and the cardiovascular system.
Infant and Dietary Nutrition: Utilized in the production of hypoallergenic infant formulas (since histidine is an essential amino acid for infants), as well as in premium-grade medical and sports nutrition.
Biotechnology and Cell Culture Media: Serves as an essential component of nutrient media for culturing cell lines and microorganisms in both R&D and industrial bio-manufacturing.
Key Advantages
Pharmacopoeia Purity (99%+): Manufactured in strict compliance with GMP standards and international pharmacopoeias (USP, EP, BP). It features exceptionally low levels of heavy metals, chlorides, sulfates, and foreign impurities.
High Bioavailability: The L-isomer (levorotatory form) ensures maximum biological activity and easy absorption by the body without creating an excessive metabolic load.
Formulation Stability: Demonstrates excellent compatibility with other amino acids, vitamins, and excipients in liquid, solid (tablets, capsules), and powder dosage forms.
Safety and Sustainability: A product of microbiological synthesis, it is completely hypoallergenic, non-toxic, GMO-free, and contains no residual organic solvents, backed by rigorous Certificates of Analysis (CoA).
Storage & Transportation
- Store in dry, cool, and well-ventilated warehouses, in the tightly sealed original manufacturer's packaging.
- Recommended storage temperature: from +5°C to +25°C with a relative air humidity of no more than 60-65%.
- Avoid direct sunlight, exposure to moisture, and proximity to heat sources or strong foreign odors.
- Transportation is permitted by all types of covered transport in accordance with standard freight regulations. The product is classified as non-hazardous (Non-DG).
- Shelf Life: 3 years from the date of manufacture (provided packaging integrity and airtight seal are maintained).
Technical Specifications
Appearance
White or almost white crystalline powder or colorless crystals
Molecular Weight
155.15 g/mol
Assay (Main Substance)
≥ 99.0%
Specific Optical Rotation
+11,8° to +12,6°
pH (2% aqueous solution)
7.0 – 8.5
Loss on Drying
≤ 0.2%
Residue on Ignition (Sulfated Ash)
≤ 0.1%
Supply info
- Specialized multi-wall kraft paper bags with a hermetic polyethylene inner liner (25 kg net).
- Heavy-duty fiber drums (pharmaceutical grade cardboard drums) (25 kg net) for maximum protection against mechanical damage and moisture.
- Custom batch sizes can be arranged upon request to meet specific client requirements.