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Pharmaceutical Chemistry
L-Histidine Hydrochloride Monohydrate
Formula:
C6H11NO3S
GOST/CAS:
CAS 56-40-6
L-Histidine Hydrochloride Monohydrate (a highly purified essential amino acid) is a white crystalline powder that is excellently soluble in water. It serves as a key component for protein synthesis, regulation of metabolic processes, and the production of finished dosage forms (FDF). Due to its pharmaceutical purity and strict control of impurities, this product is indispensable in the manufacturing of infusion solutions, parenteral nutrition, dietary supplements, as well as in the biotechnology and cosmetics industries.
Applications
Pharmaceutical Industry: Used as an active pharmaceutical ingredient (API) and an excipient. It is included in complex amino acid solutions for infusions, as well as medications for the treatment of cardiovascular diseases, anemia, and gastrointestinal ulcers.
Biotechnology and Cell Cultures: Applied as an essential component of nutrient media for culturing mammalian cells and microorganisms in the production of recombinant proteins and vaccines.
Sports and Dietary Nutrition: Used in formulas for dietary supplements and specialized complexes to accelerate tissue recovery, enhance carnosine synthesis, support the immune system, and combat stress.
Sports and Dietary Nutrition: Used in formulas for dietary supplements and specialized complexes to accelerate tissue recovery, enhance carnosine synthesis, support the immune system, and combat stress.
Key Advantages
High Purity (Pharm Grade): Fully complies with the strict requirements of leading pharmacopoeias (Ph.Eur., USP, BP, ChP). The assay content is not less than 99.0%, with a minimal and strictly limited level of heavy metals and endotoxins.
Excellent Solubility and Stability: Easily dissolves in aqueous environments, forming a clear, colorless solution. It retains its properties and stability during standard technological processes of finished dosage form manufacturing.
Biological Activity and Safety: It is the natural L-isomer form of the amino acid for the human body. Non-toxic, fully biocompatible, and hypoallergenic when recommended dosages are observed.
Universal pH Regulator and Antioxidant: Possesses buffering properties within the physiological pH range, and effectively binds free radicals and heavy metal ions, protecting other formulation components from oxidation.
Storage & Transportation
- Store in dry, clean, and well-ventilated warehouse premises in tightly closed original packaging, protected from light.
- Recommended temperature range: +5°C to +25°C. Avoid sudden temperature fluctuations and high humidity (the product is hygroscopic).
- Avoid direct sunlight and moisture exposure to prevent caking of the powder form.
- Transportation is possible by all types of covered transport while maintaining the temperature regime. The material is not classified as a dangerous good. Shelf life is 3 years from the date of manufacture.
Technical Specifications
Appearance
White crystalline powder or colorless crystals
Molecular Mass
209.63 g/mol
Assay (on dried basis)
≥ 99.0%
Specific Optical Rotation
+8.5°C to +10.5°C
pH (5% aqueous solution)
3.5 – 4.5
Loss on Drying
7.0% – 10.0% (corresponds to monohydrate)
Residue on Ignition (sulfated ash)
≤ 0,1%
Supply info
- Industrial multi-layer paper bags with a polyethylene inner liner of 25 kg (standard for powder forms).
- Hermetic plastic or fiber drums of 25 kg.
- Custom small-scale packaging is available upon request for laboratory and pilot testing.