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Pharmaceutical Chemistry
L-Glutamic Acid
Formula:
C5H9NO4
GOST/CAS:
CAS 56-40-6
L-Glutamic Acid (Pharmaceutical Grade, Ph. Eur., USP) is a high-purity amino acid that appears as a white crystalline powder or colorless crystals. It serves as a vital neurotransmitter in the central nervous system, actively participates in protein and carbohydrate metabolism, and stimulates cognitive and metabolic processes in the brain. The product is an indispensable component in the manufacturing of pharmaceuticals, specialized dietary supplements (nutraceuticals), and cell culture media for biotechnology applications.
Applications
Finished Dosage Forms (FDF) Manufacturing: Used as an Active Pharmaceutical Ingredient (API) in formulations targeting central nervous system disorders, including schizophrenia, psychoses, epilepsy, mental retardation, and post-polio complications.
Chemical Synthesis & Pharma Chemistry: Functions as a key starting material for the synthesis of other amino acids, chelated mineral complexes, and complex organic compounds for medical purposes.
Biotechnology & Culture Media: Applied as an essential nutrient in fermentation media for cultivating microorganisms and cell cultures used in the production of antibiotics, vaccines, and enzymes.
Clinical & Dietary Nutrition: Formulated into comprehensive amino acid solutions for parenteral and enteral nutrition, as well as specialized metabolic recovery supplements.
Key Advantages
Premium Pharmacopoeial Purity: Contains 98.5% – 100.5% of the active substance, strictly complying with international Ph. Eur. and USP standards. Impurities and heavy metals are kept to absolute minimum levels.
Pronounced Neuroprotective Action: Effectively regulates nitrogen metabolism, binds and detoxifies free ammonia in brain tissues, and enhances synaptic transmission of nerve impulses.
Stability and Safety: Features a highly stable crystalline form, is of non-animal origin (suitable for vegan/halal/kosher formulations), and is completely safe when dosed correctly.
High Bioavailability: Due to its exceptional refinement, it ensures rapid absorption and consistent, predictable therapeutic efficacy within multi-component drugs.
Storage & Transportation
- Store in a dry, cool, and well-ventilated warehouse, protected from light, in the tightly closed original packaging.
- The recommended storage temperature is at controlled room temperature (not exceeding +25...30 °C).
- Avoid exposure to direct sunlight, moisture, and contact with strong oxidizing agents.
- Transportation is permissible by all types of covered transport in compliance with standard freight regulations. The product is classified as non-hazardous (not subject to ADR/IMDG regulations). Shelf life is up to 5–6 years from the date of manufacture.
Technical Specifications
Appearance
White crystalline powder or colorless crystals
Molecular Weight
147.13 g/mol
Assay (Content)
98.5 % – 100.5 % (on dry basis)
Density (at 20 °C)
1.54 g/cm³
Water Solubility (at 25 °C)
~ 11.1 g/L (sparingly soluble in cold water, freely soluble in hot water)
Specific Optical Rotation
+30.5 to +32.5
Loss on Drying (105 °C, 3 hrs)
≤ 0,1%
Sulfated Ash
≤ 0,1%
Supply info
- Multi-wall paper bags or polymer bags with an inner PE liner — 25 kg (standard commercial packaging).
- Plastic pails or jars — 1 kg and 5 kg for wholesale sampling and laboratory batches.