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L-Tryptophan
Pharmaceutical Chemistry

L-Tryptophan

Formula: C₁₁H₁₂N₂O₂ GOST/CAS: CAS 73-22-3

L-Tryptophan (Pharmaceutical Grade) is an essential amino acid required for the synthesis of vital proteins, serving as a direct biochemical precursor to serotonin ("the happiness hormone"), melatonin ("the sleep hormone"), and niacin (vitamin B3). The product is a white or almost white crystalline powder, highly purified and fully compliant with strict pharmacopoeia purity standards (USP/EP/BP). Due to its high biological activity, L-Tryptophan is an indispensable component in the production of sedatives, antidepressants, sleep regulation remedies, as well as complex amino acid solutions for parenteral nutrition and specialized dietary supplements.

Applications

Production of Finished Dosage Forms: Used as an Active Pharmaceutical Ingredient (API) in formulations targeting depressive disorders, anxiety states, chronic fatigue syndrome, and sleep disturbances (insomnia).
Infusion Solutions & Parenteral Nutrition: Included in comprehensive amino acid solutions used in the hospital sector to restore protein balance in post-operative patients or those suffering from severe wasting.
Dietary Supplements (Nutraceuticals): Acts as a key ingredient in complexes designed to support the nervous system, improve mood, reduce stress levels, and regulate circadian rhythms.
Specialized & Sports Nutrition: Applied in product formulations aimed at accelerating body recovery following intense psycho-emotional and physical stress.

Key Advantages

Pharmaceutical Purity (High Purity): Minimal impurity content and strict compliance with international standards (USP, EP) guarantee maximum safety for both injectable and oral dosage forms.
High Bioavailability: Easily absorbed by the body, rapidly crosses the blood-brain barrier, and actively integrates into the metabolic pathways of neurotransmitter synthesis.
Natural Mechanism of Action: Gently regulates emotional balance and sleep phases without causing addiction, withdrawal syndrome, or daytime drowsiness when the recommended dosage is followed.
Stability in Formulations: Exhibits excellent technological properties, blends easily with other dry components, and remains stable during the manufacturing process of tablets, capsules, and powder mixes.

Storage & Transportation

  • Store in a dry, cool, light-protected place in the original, tightly closed packaging.
  • Recommended storage temperature: from +5°C to +25°C with a relative air humidity of no more than 70%.
  • Avoid exposure to direct sunlight, moisture, and strong foreign odors.
  • Transportation is carried out by all types of covered transport in accordance with regular freight regulations. The product is not classified as dangerous goods (Class 9 SMGS/ADR is absent).
  • Shelf Life: 3 years from the date of manufacture.

Technical Specifications

Appearance White or almost white crystalline powder or crystals
Molecular Weight 204.23 g/mol
Assay (Purity) ≥ 98.5% – 101.5% (calculated on the dried substance)
Solubility in Water (at 20°C) Approx. 11.4 g/L (sparingly soluble, solubility increases with heating)
Specific Optical Rotation -31.1° to -32.5°
Loss on Drying ≤ 0.3%
Sulfated Ash ≤ 0.1%

Supply info

  • Supplied in airtight double-layer plastic bags placed inside dense fiber drums (kraft drums) containing 25 kg net weight.
  • Customized packaging options are available upon request and prior agreement.

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Merit Chemicals