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Pharmaceutical Chemistry
Metamizole Sodium
Formula:
C13H16N3NaO4S
GOST/CAS:
CAS 68-89-3 / 5907-38-0
Metamizole Sodium (a pyrazolone derivative) is a highly effective, water-soluble chemical raw material that serves as a key Active Pharmaceutical Ingredient (API) for the manufacturing of analgesic and antipyretic medications. The product is a white or almost white crystalline powder, odorless, and freely soluble in water. Due to its potent mechanism of inhibiting prostaglandin synthesis, metamizole sodium is an indispensable component in the pharmaceutical industry for formulating finished dosage forms, such as tablets, injection solutions, and capsules with powerful pain-relieving properties.
Applications
Pharmaceutical Manufacturing: Used as the primary active substance (bulk powder) for the production of monocomponent analgesics.
Injection Solutions Production: Due to its excellent solubility in water, it is widely utilized in formulating sterile ampoule solutions for emergency medicine.
Combination Drugs: Integrated into complex multi-component pharmaceuticals (combined with antispasmodics, anticholinergics, or caffeine) to achieve a synergistic therapeutic effect.
Veterinary Medicine: Employed in the production of veterinary drugs aimed at relieving pain syndromes and reducing febrile conditions in animals.
Key Advantages
Powerful Analgesic Effect: Rapidly and effectively manages pain syndromes of various origins, including headaches, toothaches, neuralgia, and post-operative conditions.
Excellent Solubility: High dissolution rates in aqueous environments ensure process stability during the manufacturing of liquid dosage forms.
Pronounced Antipyretic Action: Features strong fever-reducing properties that outperform many standard anti-inflammatory components.
Processing Stability: The physical and chemical characteristics of the substance allow for its seamless use in high-speed direct compression tableting processes.
Storage & Transportation
- Store in tightly closed original factory packaging in a dry, dark place at a temperature not exceeding 25 °C.
- Protect from direct sunlight and moisture exposure, as the material is hygroscopic and light-sensitive.
- Transportation is permissible by all modes of covered transport in strict compliance with the freight regulations applicable to each transport type. Shelf life ranges from 3 to 5 years (depending on the manufacturer's specification).
Frequently bought together
Technical Specifications
Appearance
White or almost white crystalline powder
Molecular Mass
~ 351.4 g/mol (Monohydrate)
Solubility
Freely soluble in water, sparingly soluble in ethanol
Assay (Active Substance)
99.0% – 101.0% (on the dried basis)
pH (5% aqueous solution)
6.0 – 7.5
Loss on Drying (Moisture)
4.9% – 5.5%
Residual Solvents
Complies with EP / USP standards
Supply info
- Multi-wall branded paper bags with an inner polyethylene liner — 25 kg.
- Fibre drums (cardboard drums) — 25 kg / 50 kg (the optimal and industry-standard packaging for pharmaceutical substances).