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Pharmaceutical Chemistry
Tenoxicam
Formula:
C13H11N3O4S2
GOST/CAS:
CAS: 59803-98-4
Tenoxicam is a highly effective non-steroidal anti-inflammatory drug (NSAID) belonging to the oxicam class. The product is a yellow to greenish-yellow crystalline powder, practically insoluble in water. Due to its potent analgesic, anti-inflammatory, and antipyretic properties, combined with a prolonged half-life, Tenoxicam serves as an indispensable Active Pharmaceutical Ingredient (API) for manufacturing finished dosage forms targeted at acute and chronic musculoskeletal disorders.
Applications
Oral Dosage Forms Manufacturing: Used as the core active ingredient in the production of tablets and capsules. It ensures a long-acting therapeutic effect, allowing convenient once-daily dosing for patients.
Injectable Dosage Forms Manufacturing: Utilized in formulating lyophilisates and solutions for intramuscular and intravenous administration. Crucial for rapid acute pain management in hospital and emergency settings.
Rheumatology & Orthopedics: The end-use medications are indicated for treating rheumatoid arthritis, osteoarthritis, ankylosing spondylitis (Ankylosing Spondylitis), gout, and various joint syndromes.
Neurology & General Therapy: Incorporated into formulations designed to relieve neuralgia, myalgia, lumbago, as well as post-operative and post-traumatic pain.
Key Advantages
High Anti-Inflammatory Activity: Efficiently inhibits COX-1 and COX-2 isoenzymes, reducing prostaglandin synthesis at the site of inflammation to deliver a powerful analgesic response.
Prolonged Action (Extended Half-Life): Features a long elimination half-life (approximately 60–75 hours), enabling a patient-friendly once-a-day treatment regimen that significantly improves patient compliance.
Stability & High Purity Profile: Manufactured in strict compliance with GMP standards, ensuring a minimal impurity profile which guarantees the safety, shelf-life, and stability of the finished drug forms.
Proven Clinical Efficacy: Tenoxicam is well-researched with a predictable safety profile and excellent oral bioavailability (close to 100%).
Storage & Transportation
- Store in a dry, light-protected area in the original tightly closed container at a temperature not exceeding +25 °C.
- Protect from moisture and direct sunlight.
- Transportation is carried out via all types of covered transport complying with regulations for pharmaceutical cargo. The product is classified as non-hazardous for transport.
- Shelf Life: 3 to 5 years from the manufacturing date (depending on the specific manufacturer's specifications).
Technical Specifications
Appearance
Yellow to greenish-yellow crystalline powder
Molecular Mass
337.4 g/mol
Assay (Core Substance)
≥ 99.0%
Melting Point
~205 °C (with decomposition)
Solubility
Practically insoluble in water, slightly soluble in ethanol, soluble in dimethylformamide and alkaline solutions
Loss on Drying
≤ 0.5%
Supply info
- Industrial double polyethylene bags packed inside fiber drums of 10 kg or 25 kg (standard regulatory packaging for APIs).
- Every batch is accompanied by a comprehensive documentation package: COA (Certificate of Analysis), DMF (Drug Master File status), and GMP Certificate.