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Pharmaceutical Chemistry
Metronidazole
Formula:
C6H9N3O3
GOST/CAS:
CAS 443-48-1
Metronidazole is a highly effective active pharmaceutical ingredient (API) with a broad spectrum of antiprotozoal and antibacterial activity. The product presents as a white or yellowish-green crystalline powder, slightly soluble in water and alcohol. Due to its high stability, chemical purity, and proven therapeutic efficacy, metronidazole serves as an indispensable essential raw material for the manufacturing of finished dosage forms (FDF) in modern pharmaceutical and veterinary industries.
Applications
Pharmaceutical Industry: Used as an Active Pharmaceutical Ingredient (API) for manufacturing a wide range of medicinal products, including tablets, suppositories, infusion solutions, as well as topical gels and ointments.
Dentistry: Widely utilized in formulation of combination dental gels and pastes for treating periodontitis, gingivitis, and other inflammatory processes of the oral cavity.
Cosmeceuticals & Dermatology: Incorporated into specialized therapeutic creams, gels, and lotions for the treatment of rosacea, acne, and demodicoses.
Key Advantages
Broad Spectrum of Activity: Highly effective against most anaerobic microorganisms and protozoa (Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia, etc.).
High Chemical Purity: The substance fully complies with the strict requirements of leading pharmacopoeias (EP, BP, USP), minimizing the presence of impurities.
Processing Stability: The powder is resilient to technological processes such as compression, blending, and sterilization (for solution manufacturing).
Bioavailability & Safety: Easily combines with various excipients and other APIs (e.g., chlorhexidine or miconazole), ensuring high synergistic performance.
Storage & Transportation
- Store in dry, clean, cool warehouse areas in tightly closed original packaging, protected from light and away from heat sources.
- Recommended storage temperature range: +15°C to +25°C.
- Avoid contact with strong oxidizing agents.
- Transportation is permissible by all types of covered transport while maintaining the required temperature control. The product is not classified as dangerous goods (under standard API transport regulations).
- Shelf Life: 3–5 years from the date of manufacture (depending on the producing facility).
Technical Specifications
Appearance
White or yellowish-green crystalline powder, odorless
Assay (Main Substance)
99.0% – 101.0% (on dried basis)
Melting Point
159°C – 163°C
Loss on Drying
max 0.5%
Sulfated Ash
max 0.1%
Heavy Metals
max 20 ppm
Supply info
- Fiber drums with double polyethylene inner liners, 25 kg net weight.
- Custom small-scale packaging for laboratory and pilot production available upon request.