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Pharmaceutical Chemistry
Ciprofloxacin hydrochloride
Formula:
C17H18FN3O3
GOST/CAS:
CAS 86393-32-0
Ciprofloxacin Hydrochloride is a highly effective, broad-spectrum antimicrobial agent belonging to the second-generation fluoroquinolones. The substance is a white to slightly yellowish crystalline powder, soluble in water and sparingly soluble in ethanol. Due to its potent inhibitory effect on bacterial DNA gyrase, it exhibits a pronounced bactericidal effect. It serves as an essential, foundational raw material for the production of a wide range of finished dosage forms (FDF) in the modern pharmaceutical and veterinary industries.
Applications
Finished Dosage Forms (FDF) Production: Used as the primary active pharmaceutical ingredient (API) in the manufacturing of tablets, capsules, infusion solutions, as well as ophthalmic and otic drops.
Veterinary Medicine: Applied as a key component in the production of antibacterial drugs for livestock, poultry, and aquaculture (powders, oral solutions, injectable forms).
Research & Development: Utilized in microbiological laboratories and R&D centers for sterility control, creation of selective media, and antimicrobial susceptibility testing.
Key Advantages
Broad Spectrum of Activity: Demonstrates high efficacy against most gram-negative and gram-positive microorganisms, including strains resistant to penicillins and cephalosporins.
High Purity Grade: Fully complies with strict international quality standards (EP, USP, BP) with minimal impurity levels, ensuring excellent stability of the finished dosage forms.
Excellent Bioavailability: Easily undergoes technological processing (granulation, compression, dissolution), ensuring rapid absorption of the active substance in the final drug product.
Storage Stability: The crystalline structure of the hydrochloride salt provides superior resistance to temperature fluctuations and oxidation compared to ciprofloxacin base.
Storage & Transportation
- Store in dry, clean, light-protected warehouse facilities in tightly closed original packaging at a temperature not exceeding +25 °C.
- Protect from moisture and direct sunlight.
- Transportation is permissible by all modes of covered transport while strictly maintaining the required temperature regime. The product is transported in compliance with regulations for non-hazardous cargo.
- Shelf Life: 3–5 years from the date of manufacture (depending on the manufacturing plant and packaging integrity).
Technical Specifications
Appearance
White to slightly yellowish crystalline powder, hygroscopic.
Assay (Content)
98.5% – 101.0% (on anhydrous basis)
Solubility
Soluble in water, sparingly soluble in methanol, practically insoluble in acetone and dichloromethane.
pH (2.5% aqueous solution)
3.5 – 4.5
Loss on Drying
4.7% – 6.7%
Sulfated Ash
Not more than 0.1%
Heavy Metals
Not more than 20 ppm
Supply info
- Packed in 25 kg fiber drums (cardboard drums) containing double-layer sealed plastic bags inside.
- Custom small-scale packaging (from 1 kg to 5 kg) is available for laboratory and R&D purposes upon request and agreement.