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Pharmaceutical Chemistry
Lidocaine Hydrochloride
Formula:
C14H22N2O
GOST/CAS:
CAS 6108-05-0 / USP / EP / ФС
Lidocaine Hydrochloride is a highly effective local anesthetic and antiarrhythmic agent, widely utilized as a core Active Pharmaceutical Ingredient (API) in the pharmaceutical industry, aesthetic medicine, and specialized cosmetics manufacturing. The product is a white or almost white crystalline powder, freely soluble in water and alcohol. Due to its rapid onset of action, deep anesthetic effect, and excellent stability in formulations, Lidocaine Hydrochloride is an indispensable raw material for creating stable and high-performance medicinal forms and pain-relief products.
Applications
Pharmaceutical Manufacturing: Used as an active ingredient for the production of injection solutions, ophthalmic and otic drops, topical sprays for mucosal numbing, as well as rectal suppositories and ointments.
Cosmetology & Aesthetic Medicine: Applied as a key component in professional numbing creams, gels, and lotions ("primary" and "secondary" anesthesia) used prior to tattooing, depilation, mesotherapy, and contour plastics (dermal fillers).
Dentistry: An essential component for formulating topical gels and solutions for infiltration and nerve block anesthesia in therapeutic and surgical dental procedures.
Veterinary Medicine: Widely used in manufacturing veterinary pharmaceuticals for surgical interventions, nerve blocks, and acute pain management in animals.
Key Advantages
Rapid Onset & Deep Anesthesia: Ensures fast-acting pain relief (within 1 to 5 minutes depending on the application form) with an optimal duration of action.
Formulation Stability: The crystalline hydrochloride structure dissolves easily and shows excellent compatibility with most preservatives, vasoconstrictors (e.g., epinephrine), and gelling agents.
High Purity Grade (USP/EP): Strict compliance with leading global pharmacopoeia standards guarantees the absence of toxic impurities and ensures high safety when properly dosed.
Manufacturing Versatility: Perfectly suited for developing diverse dosage forms—ranging from liquids and gases (sprays) to semi-solids (creams, gels) and solid formulations.
Storage & Transportation
- Store in dry, clean, light-protected warehouse premises in tightly sealed original packaging, away from heat sources and open flames.
- Recommended storage temperature: +15°C to +25°C. Avoid sudden temperature fluctuations and high humidity exposure.
- The product is classified as a potent substance depending on local regional regulations and requires strict accounting/inventory control.
- Transportation is permitted by all modes of covered transport, provided container airtightness is maintained. Shelf life — 5 years from the date of manufacture.
Technical Specifications
Appearance
White or almost white crystalline powder, odorless with a bitter taste
Assay (Main Substance)
99.0% – 101.0% (on the dried basis)
Solubility
Very soluble in water, freely soluble in 96% ethanol
Melting Point
~ 75°C – 79°C
pH (0.5% Aqueous Solution)
4.0 – 5.5
Sulfated Ash / Heavy Metals
Not more than 0.1% / Not more than 0.002%
Loss on Drying (Water Content)
5.0% – 7.0%
Supply info
- Fiber or plastic drums with a double tight-seal polyethylene inner liner, 25 kg net weight (standard factory packaging).
- Custom pre-packaging in 1 kg and 5 kg bags is available upon request for R&D purposes and small-scale batch production.