Back to Catalog
Pharmaceutical Chemistry
Edaravone
Formula:
C10H10N2O
GOST/CAS:
CAS 89-25-8
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a highly effective medicinal substance, acting as a potent antioxidant and free radical scavenger. The product comes in the form of a white or almost white crystalline powder. Due to its exceptional ability to scavenge active oxygen species and prevent lipid peroxidation, edaravone protects brain and spinal cord cells from ischemic damage and apoptosis. It is an indispensable raw material for the manufacturing of modern neuroprotective pharmaceutical products.
Applications
Production of Injectable Drugs: Used as an Active Pharmaceutical Ingredient (API) for the formulation of infusion solutions applied during the acute phase of ischemic stroke to minimize neurological deficits.
Orphan Disease Therapy: Serves as a core component in the combination therapy for Amyotrophic Lateral Sclerosis (ALS / Lou Gehrig's disease), slowing down the progression of functional disabilities in patients.
Pharmaceutical Research: Widely utilized in R&D laboratories for developing combined antioxidant and cardioprotective agents, as well as therapeutics for traumatic brain injuries.
Ophthalmology and Eye Drops: Currently researched and implemented as a component for retinal protection and the comprehensive treatment of other degenerative eye conditions.
Key Advantages
High Neuroprotective Activity: Effectively crosses the blood-brain barrier (BBB), immediately neutralizing hydroxyl radicals and preventing neuronal death in the "ischemic penumbra" zone.
Pharmaceutical Purity: Manufactured in strict compliance with international GMP standards, which guarantees a minimal level of related impurities and heavy metals.
Proven Therapeutic Value: Included in international clinical protocols for treating severe neurodegenerative and vascular pathologies, ensuring steady demand from drug manufacturers.
Molecular Stability: Exhibits excellent physical and chemical stability, enabling the development of finished dosage forms with a long shelf-life.
Storage & Transportation
- Store in dry, clean, cool warehouse areas in tightly closed original packaging, protected from light and away from heat sources.
- Recommended storage temperature range: +15 °C to +25 °C (avoid overheating and exposure to direct sunlight).
- Avoid contact with strong oxidizing agents, alkalis, and acids, as they may cause chemical degradation of the substance.
- Transportation is possible via all types of covered transport while maintaining the required temperature regime. This material requires careful handling. Shelf life — 3 years from the date of manufacture.
Technical Specifications
Appearance
White or almost white crystalline powder, odorless
Assay (Quantitative Determination)
Not less than 99.0%
Melting Point
127.0 °C – 131.0 °C
Loss on Drying
Not more than 0.5%
Sulfated Ash
Not more than 0.1%
Heavy Metals
Not more than 10 ppm
Residual Organic Solvents
Meets requirements (USP/Ph. Eur.)
Supply info
- Double airtight polyethylene bags packed into light-protected plastic or fiber drums of 10 kg / 25 kg.
- Small packaging in aluminum foil bags from 1 kg for laboratory research and pilot-scale batches.
- Customized packaging sizes and materials can be provided upon agreement with the customer.