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Pharmaceutical Chemistry
Thiotriazolin
Formula:
C9H16N4O3S
GOST/CAS:
CAS: 147511-69-1
Thiotriazolin is a highly effective Active Pharmaceutical Ingredient (API) exhibiting pronounced antioxidant, cardioprotective, hepatoprotective, and anti-ischemic properties. The product comes as a white or white with a slight yellowish tinge crystalline powder, readily soluble in water. Due to its ability to stabilize cell membranes and reduce free radical levels, Thiotriazolin is an essential component for manufacturing modern cardiological, ophthalmological, and hepatoprotective medicinal products.
Applications
Pharmaceutical Industry (Cardiology): Used as the primary active ingredient in the production of injectables and tablets for the treatment of ischemic heart disease (IHD), myocardial infarction, angina pectoris, and cardiac arrhythmias.
Hepatoprotector Manufacturing: Incorporated into complex therapies for chronic hepatitis of various etiologies, liver cirrhosis, and toxic hepatocyte damage.
Ophthalmology: Serves as a base component for formulation of eye drops designed to treat corneal injuries, degenerative eye diseases, and burns.
Combination Drugs: Widely utilized in combination with other APIs (e.g., Piracetam) to manufacture nootropic and neuroprotective medications.
Key Advantages
High Antioxidant Activity: Inhibits the activation of lipid peroxidation (LPO) processes, binds free radicals, and boosts the body's natural antioxidant defense system.
Cardio- and Hepatoprotection: Prevents the destruction of cardiomyocytes and hepatocytes, minimizes the severity of myocardial ischemia, and enhances metabolic processes within tissues.
Pharmaceutical Purity: Manufactured in strict compliance with GMP standards, ensuring minimal impurity profiles and excellent stability of finished dosage forms.
Cost-Efficiency and Bioavailability: Features excellent water solubility, which simplifies the technological process of liquid formulation manufacturing and ensures high bioavailability.
Storage & Transportation
- Store in dry, clean, light-protected warehouse facilities in the original, tightly closed manufacturer's packaging at a temperature not exceeding +25 °C.
- Avoid exposure to direct sunlight, moisture, and heat sources to prevent degradation of the active substance.
- Transportation is permissible by all types of covered transport while strictly maintaining the temperature regime. The product must be securely protected against mechanical damage during logistics.
- Shelf life of the substance — 3 years from the date of manufacture (provided that the integrity and airtightness of the packaging are maintained).
Technical Specifications
Appearance
White or white with a slight yellowish tinge crystalline powder, odorless
Assay (On Dried Basis)
Not less than 98.5% – 101.5%
Solubility
Freely soluble in water, sparingly soluble in alcohol
Loss on Drying
Not more than 0.5%
Sulfated Ash
Not more than 0.1%
pH (5% aqueous solution)
6.0 – 7.5
Heavy Metals
Not more than 0.001% (10 ppm)
Supply info
- Pharmaceutical-grade double polyethylene bags packed inside plastic or fiber drums containing 10 kg / 25 kg (for industrial manufacturing).
- Custom packaging options in smaller specialized containers are available upon prior agreement.