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Pharmaceutical Chemistry
Nicotinamide
Formula:
C6H6N2O
GOST/CAS:
CAS 98-92-0
Nicotinamide (niacinamide) is a highly purified pharmaceutical-grade component acting as a vital B-complex vitamin (Vitamin B3, Vitamin PP). The product is a white crystalline powder, exceptionally soluble in water and ethanol. Unlike nicotinic acid, it does not cause peripheral vasodilation ("flushing" or redness), making it an ideal active ingredient for medicine, dietary supplements, and premium cosmetics. Due to its essential role in cellular metabolism, tissue regeneration, and the synthesis of crucial coenzymes (NAD and NADP), nicotinamide is an indispensable component in modern pharmaceutical and beauty industries.
Applications
Pharmaceutical Manufacturing: Used as an active pharmaceutical ingredient (API) in multivitamin complexes, injectable solutions, and tablets for the prevention and treatment of pellagra, vitamin B3 deficiency, and in the complex therapy of metabolic disorders.
Cosmeceuticals and Dermatology: Widely incorporated into creams, serums, and lotions (commonly known as Niacinamide). It effectively combats acne, regulates sebum production, strengthens the skin's hydrolipid barrier, lightens hyperpigmentation, and stimulates collagen synthesis.
Dietary Supplements & Sports Nutrition: Included in dietary supplement formulations to support the nervous system, enhance cognitive functions, optimize energy metabolism, and improve the overall condition of skin, hair, and nails.
Veterinary Medicine & Feed Additives: Applied to enrich the diets of livestock and poultry to prevent hypovitaminosis, improve feed conversion, and stimulate healthy growth.
Key Advantages
High Purity Grade (Ph. Eur. / USP): Fully complies with stringent international quality standards for pharmaceutical raw materials, ensuring the absolute absence of hazardous impurities and consistent therapeutic efficacy.
Gentle Action Without Flushing: Unlike pure nicotinic acid, it does not trigger vasodilation, burning sensations, or skin redness, allowing for safe usage in high topical and oral concentrations.
Excellent Stability: Demonstrates outstanding resistance to light, heat, and oxidation. It fully retains its physicochemical and therapeutic properties across a broad pH range.
Biocompatibility and Safety: Readily absorbed by the body, hypoallergenic at recommended dosages, non-toxic, and completely biodegradable in the environment.
Storage & Transportation
- Store in dry, cool, and well-ventilated warehouse premises in tightly sealed original packaging, protected from light, and away from strong oxidizing agents.
- Recommended temperature range: +5°C to +25°C. Protect from moisture and high humidity to prevent the powder from caking.
- Avoid direct exposure of sunlight to the packaging.
- Transportation is permissible by all modes of covered transport in accordance with standard cargo regulations. The product is not classified as a dangerous good (no UN hazard classification applies). Shelf life is 3 years from the date of manufacture.
Technical Specifications
Appearance
White or almost white crystalline powder or colorless crystals
Molecular Weight
122.12 g/mol
Assay (Main Substance)
≥ 99.0% (calculated on the dried substance, EP/USP standard)
Melting Point
128°C – 131°C
pH (5% aqueous solution)
6.0 – 7.5
Loss on Drying
≤ 0.5%
Supply info
- 25 kg fibre (cardboard) drums with a double polyethylene inner liner (standard packaging for industrial manufacturing).
- 1 kg and 5 kg hermetically sealed aluminum foil bags (for small wholesale batches and laboratory use).