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Pharmaceutical Chemistry
Thioctic Acid
Formula:
C8H14O2S2
GOST/CAS:
CAS 1077-28-7 / USP / EP / BP
Thioctic acid (alpha-lipoic acid) is a highly purified Active Pharmaceutical Ingredient (API) acting as a potent endogenous antioxidant. The product is supplied as a light yellow crystalline powder, practically insoluble in water but freely soluble in alcohol. Due to its unique physicochemical profile (being both fat- and water-soluble), it effectively binds free radicals, protects cells from oxidative damage, and regulates carbohydrate and lipid metabolism. It serves as an essential component in the manufacturing of solid and liquid dosage forms, as well as premium dietary supplements.
Applications
Pharmaceutical Industry: Utilized as an active pharmaceutical ingredient (API) for manufacturing medicines targeting diabetic and alcoholic polyneuropathy, liver diseases (fatty degeneration, cirrhosis, hepatitis), and various intoxications.
Nutraceuticals & Dietary Supplements: Incorporated into metabolic, antioxidant, and vitamin-mineral complexes, weight management formulations, blood sugar control products, and cardiovascular health supplements.
Cosmeceuticals & Anti-Aging Products: Used in specialized topical creams, serums, and rejuvenating masks to shield the skin from oxidative stress, prevent collagen glycation, and boost cellular metabolism.
Sports Nutrition: Added to sports formulations to optimize energy production, accelerate post-workout recovery, and enhance tissue sensitivity to insulin.
Key Advantages
Universal Antioxidant Activity: Operates efficiently in both the lipid (fat) and aqueous (water) phases of cells, neutralizing a wide spectrum of free radicals and regenerating other vital antioxidants (vitamins C and E, glutathione).
Pharmaceutical Grade Purity: Fully complies with strict international quality standards (USP/EP/BP), ensuring minimal impurity levels, excellent API stability, and high safety profiles in finished products.
Metabolic Regulation: Effectively assists in lowering blood glucose levels, reducing insulin resistance, and optimizing cholesterol metabolism.
Excellent Formulation Stability: Demonstrates high compatibility with a wide range of excipients typically used in encapsulation, tableting, and coating processes.
Storage & Transportation
- Store in a dry, dark, and well-ventilated warehouse in the tightly closed original packaging.
- Recommended Temperature Range: Do not exceed 25 °C. Protect from excessive heat.
- Keep away from direct sunlight, strong oxidizing agents, and moisture.
- Transport is permissible via all types of covered transport, provided temperature conditions are maintained. The product is not classified as a dangerous good for transport.
- Shelf Life: 3 years from the date of manufacture.
Technical Specifications
Appearance
Light yellow crystalline powder with a faint characteristic odor
Molecular Weight
206.33 g/mol
Assay (Main Substance)
≥ 99.0%
Melting Point
60.0 °C – 62.0 °C
Residual Solvents
Meets USP / EP requirements
Heavy Metals
≤ 10 ppm
Loss on Drying
≤ 0,5%
Supply info
- Industrial fiber drums of 25 kg net weight, equipped with a double inner polyethylene liner for superior moisture and light protection.
- Smaller custom packaging options are available upon request for laboratory trials and pilot batches.