Back to Catalog
Pharmaceutical Chemistry
Povidone K30 (PVP K30)
Formula:
C6H9NO
GOST/CAS:
CAS 9003-39-8
Povidone K30 (Polyvinylpyrrolidone K30) is a highly purified, water-soluble polymer that serves as an indispensable excipient in the modern pharmaceutical industry. The product is supplied as a white to slightly off-white, hygroscopic powder with a faint, characteristic odor. Due to its unique chemical structure, K30 possesses excellent binding, stabilizing, and solubilizing properties, making it a key component in the formulation of solid, liquid, and semi-solid dosage forms.
Applications
Tablet and Capsule Manufacturing: Utilized as a highly effective binder in wet granulation and direct compression processes. It ensures excellent tablet hardness and controlled, compliant disintegration times.
Bioavailability Enhancement: Acts as a powerful solubilizer for poorly water-soluble Active Pharmaceutical Ingredients (APIs). It aids in forming stable solid dispersions, significantly increasing the dissolution rate of drugs.
Liquid Dosage Forms: Employed as a stabilizer in suspensions, emulsions, and syrups. It prevents the crystallization of active substances (especially in highly concentrated solutions) and retards particle sedimentation.
Topicals and Coatings: Used in the formulation of ointments, gels, and transdermal patches to improve adhesion and prolong drug release. It is also a staple ingredient in film-coating formulations for tablets.
Key Advantages
High Binding Efficiency: Reduces the brittleness of the tablet mass, allowing the production of robust tablets even at low polymer concentrations while maintaining the target API release profile.
Excellent Solubility: Dissolves rapidly and completely in water, alcohols, and other polar solvents, leaving no residue or lumps during processing.
Chemical Inertness: Does not interact with most active ingredients or other excipients, ensuring the long-term chemical stability of the finished drug product.
Safety & Regulatory Compliance: Fully biocompatible, non-toxic, and non-irritating. The product quality strictly complies with the requirements of major international pharmacopoeias (Ph.Eur., USP/NF, BP, JP).
Storage & Transportation
- Store in dry, cool, and light-protected warehouses in tightly sealed original packaging, as the product is highly hygroscopic.
- Protect from moisture and direct sunlight.
- Recommended storage temperature range is between +5°C and +30°C.
- Transportation can be carried out by all types of covered transport in accordance with standard cargo regulations. The product is classified as non-hazardous for transport.
- Shelf Life: 3 years from the date of manufacture.
Technical Specifications
Appearance
White or almost white powder or granules
K-Value
27.0 – 32.4
Molecular Weight
~40,000 – 50,000 g/mol
pH (5% aqueous solution)
3.0 – 7.0
Water Content
≤ 5.0%
Sulfated Ash
≤ 0.1%
Residual Monomer (NVP)
≤ 10 ppm (0.001%)
Heavy Metals
≤ 10 ppm
Supply info
- Packed in multi-layer paper bags or airtight fiber drums with an inner polyethylene liner at 25 kg net weight (optimized for moisture protection).
- Available for delivery in full pallet quantities or as individual packaging units for pilot and R&D batches.