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Pharmaceutical Chemistry
Esmolol Hydrochloride
Formula:
C16H26ClNO4
GOST/CAS:
CAS 81161-17-1
Esmolol Hydrochloride is a highly effective, ultra-short-acting cardioselective adrenergic receptor blocker, available as an Active Pharmaceutical Ingredient (API). It is characterized by an exceptionally rapid onset and a brief duration of action, making it an indispensable component for manufacturing injectable dosage forms (solutions and concentrates for infusion) used in intensive care units, cardiac resuscitation, and operating rooms.
Applications
Finished Dosage Form (FDF) Manufacturing: Used as the active pharmaceutical ingredient (API) for formulation into intravenous injections and sterile infusion solutions.
Cardiology and Critical Care: Incorporated into emergency medications designed for rapid heart rate (HR) control in patients with supraventricular tachycardia, atrial fibrillation, and acute hypertension during perioperative periods.
Anesthesiology: Utilized in formulations aimed at preventing or managing undesirable hemodynamic responses (such as sudden spikes in blood pressure or tachycardia) during endotracheal intubation and emergence from anesthesia.
Key Advantages
Ultra-Short Duration of Action: With an elimination half-life of approximately 9 minutes, it provides excellent titratability and an outstanding safety profile (its pharmacological effects dissipate rapidly once the infusion is discontinued).
High Cardioselectivity: Preferentially blocks adrenergic receptors in cardiac tissue, significantly minimizing the risk of bronchospasm in patients with co-existing airway diseases.
Pharmaceutical Excellence: Manufactured in strict compliance with international compendial standards (USP/EP), ensuring exceptionally low impurity profiles, high purity, and chemical stability.
Process-Friendly Characteristics: Highly soluble in water and alcohol, allowing for smooth processing and formulation during the compounding of sterile parenterals.
Storage & Transportation
- Store in a dry, dark place protected from moisture, in original tightly sealed containers at a temperature not exceeding 25°C.
- Keep away from direct sunlight, open flames, and strong sources of heat.
- Transportation is permitted by all modes of covered transport provided that the required temperature controls are maintained. The product is not classified as hazardous for transport (no ADR classification applies).
- Shelf Life: 2–3 years from the date of manufacture, provided the original packaging remains hermetically sealed.
Technical Specifications
Appearance
White or almost white crystalline powder
Assay (HPLC)
98.0% – 102.0% (on dried basis)
Solubility
Freely soluble in water, freely soluble in ethanol
Melting Point
85°C - 90°C
Loss on Drying
Not more than 0.5%
Sulfated Ash
Not more than 0.1%
Heavy Metals
Not more than 20 ppm
Supply info
- Sealed double polyethylene bags packed inside fiber drums / cardboard drums of 10 kg and 25 kg net weight.
- Small-scale packaging available for laboratory evaluation, trials, and R&D purposes (upon request).
- Fully accompanied by a comprehensive documentation package (CoA, DMF, and the manufacturer's GMP certificate).