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Pharmaceutical Chemistry
Escin
Formula:
C55H86O24
GOST/CAS:
CAS: 6805-41-0
Escin is a highly purified mixture of natural triterpene saponins derived from the seeds of the horse chestnut (Aesculus hippocastanum). It acts as a potent venotonic, angioprotective, and anti-edematous agent. The product is widely utilized in the pharmaceutical and cosmetic industries as a key Active Pharmaceutical Ingredient (API) for manufacturing topical, oral, and liquid dosage forms aimed at treating venous circulation disorders.
Applications
Pharmaceutical Manufacturing (Capsules, Tablets): Used as a core component in systemic therapies for chronic venous insufficiency (CVI), varicose veins, and post-thrombotic syndrome.
Topical Medications (Gels, Ointments): Formulated into local applications for rapid relief of edema, inflammation, and hematomas, as well as for the comprehensive treatment of sports injuries and bruises.
Specialized Cosmeceuticals: Incorporated into leg creams (for "heavy legs" relief and varicose vein prevention), anti-couperose (spider veins) formulations, and anti-puffiness eye contour products.
Proctological Preparations: Included in suppositories and ointments for symptomatic therapy and strengthening of the vascular walls in hemorrhoidal treatments.
Key Advantages
Pronounced Capillary-Protective Effect: Reduces capillary permeability and fragility by inhibiting the activity of lysosomal enzymes that break down proteoglycans in vascular walls.
Powerful Anti-Edematous Action: Stimulates the production of prostaglandins, increases venous wall tone, and improves lymphatic drainage, effectively eliminating fluid retention in tissues.
High Purity Grade: A standardized extract with guaranteed active escin content, completely purified from ballast substances and toxic impurities.
Formulation Synergy: Combines excellently with other angioprotectors (such as troxerutin, rutin) and anticoagulants (like heparin), enhancing their overall therapeutic efficacy.
Storage & Transportation
- Store in a dry, cool, and dark place, in the tightly closed original packaging.
- Recommended storage temperature: +15 C to +25 C. Do not freeze and avoid excessive heat exposure.
- Protect from moisture and direct sunlight.
- Transportation is permissible by all types of covered transport in strict accordance with non-hazardous cargo regulations. Shelf life — 3 years from the production date, provided the original packaging remains hermetically sealed.
Technical Specifications
Appearance
White to light cream (yellowish) amorphous powder
Molecular Weight
~1131.26 g/mol
Assay (Purity)
≥ 95.0% (or 20% for standardized dry extracts)
Solubility
Sparingly soluble in water, freely soluble in ethanol and methanol
pH (1% aqueous solution)
3.5 – 5.5
Loss on Drying
≤ 5.0%
Supply info
- Industrial airtight plastic canisters / drums of 10 kg and 25 kg, equipped with a double polyethylene inner liner for superior moisture protection.
- Small-scale packaging of 1 kg and 5 kg available for laboratory testing and R&D purposes.