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Pharmaceutical Chemistry
Furosemide
Formula:
C12H11ClN2O5S
GOST/CAS:
CAS 54-31-9 / ФС
Furosemide is a highly effective medicinal substance, a fast-acting loop diuretic used as a core active component for manufacturing a wide range of dehydration and antihypertensive drugs. The product is a white or almost white crystalline powder, practically insoluble in water, and soluble in dilute solutions of alkali hydroxides. Due to its potent and rapid diuretic effect, furosemide serves as an indispensable raw material for creating stable and efficient formulations in the modern Household & Personal Care and Pharmaceutical manufacturing industries.
Applications
Production of Oral Dosage Forms: Acts as the primary active pharmaceutical ingredient (API) in tablets and capsules prescribed for the comprehensive treatment of edematous syndrome of various origins and arterial hypertension.
Production of Injectable Solutions: Utilized as a key component in liquid dosage forms (ampoules/vials) for emergency therapy requiring an immediate diuretic effect (e.g., pulmonary edema, cerebral edema, hypertensive crises).
Veterinary Medicine: Used in manufacturing veterinary pharmaceuticals to treat congestive heart failure and reduce edema in small and large domestic animals.
Pharmaceutical R&D: Widely used in laboratory practices and for developing innovative next-generation combination drug formulations.
Key Advantages
High Diuretic Activity: Blocks the reabsorption of sodium and chloride ions in the thick ascending limb of the loop of Henle, ensuring a powerful and rapid therapeutic response.
Substance Stability and Purity: Full compliance with international pharmacopoeia standards (USP/EP/BP) guarantees minimal impurity profiles and exceptional stability during large-scale manufacturing.
Cost-Efficiency and Scalability: The high concentration of the active substance reduces transportation and storage costs, allowing for easy dosage standardization on production lines.
Clinically Proven Safety Profile: Features a well-documented safety and pharmacokinetic profile, with no bioaccumulation in the body when correctly dosed.
Storage & Transportation
- Store in dry, clean, cool warehouse areas in tightly closed original packaging, protected from light and away from direct heat sources.
- Recommended storage temperature: +15°C to +25°C (in compliance with regulations for potent pharmaceutical substances).
- Avoid contact with strong oxidizing agents and acids, which may cause degradation of the API substance.
- Transportation is permissible via all types of covered transport while strictly adhering to temperature regimes and pharmaceutical cargo regulations. The substance is classified as a regulated API. Shelf life is 3–5 years from the date of manufacture (depending on the manufacturer's specification).
Technical Specifications
Appearance
White or almost white crystalline powder, odorless
Assay (Active Substance)
98.5% – 101.0%
Melting Point
Approx. 206°C (with decomposition)
Loss on Drying
Not more than 0.5%
Sulfated Ash
Not more than 0.1%
Heavy Metals
Not more than 20 ppm
Supply info
- Double polyethylene bags inside multi-layer kraft paper bags of 10 kg / 25 kg.
- Plastic or fiber drums with hermetic lids containing 25 kg for industrial-scale manufacturing.
- Customized packaging sizes and weights are available upon prior agreement.