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Pharmaceutical Chemistry
Heparin Sodium
GOST/CAS:
CAS 9041-08-1
Heparin Sodium is a highly effective, direct-acting anticoagulant. It is the sodium salt of a glycosaminoglycan extracted from the intestinal mucosa of pigs. This product serves as a vital base component for the manufacturing of a wide range of medicinal products, including injectable solutions, gels, and ointments. Due to its ability to block thrombin biosynthesis and inhibit platelet aggregation, Heparin Sodium is an indispensable raw material in the modern pharmaceutical industry and medical practice.
Applications
Production of Injectable Preparations: Serves as the main active pharmaceutical ingredient (API) in solutions for intravenous and subcutaneous administration, used for the prevention and treatment of thromboembolic diseases, as well as during cardiac and vascular surgeries.
Topical Medications: Applied as an active component in medicinal ointments, creams, and gels intended for the treatment of varicose veins, thrombophlebitis, hematomas, and sports injuries.
Medical Device Manufacturing: Used to coat the internal surfaces of catheters, probes, and blood transfusion systems to prevent clot formation.
Laboratory Diagnostics: Used as an anticoagulant in specialized blood collection tubes for blood plasma sampling and analysis.
Key Advantages
High Anticoagulant Activity: Rapidly and effectively inactivates blood clotting factors, ensuring an immediate therapeutic effect in solutions and stable local action in topical formulations.
High Purity Level: Modern extraction and filtration methods guarantee minimal content of impurities, dermatan sulfate, and proteins, significantly reducing the risk of allergic reactions.
Formulation Stability: The substance blends perfectly with standard gel bases, preservatives, and other active ingredients (e.g., allantoin or dexpanthenol).
Compliance with Standards: The product is manufactured strictly in accordance with GMP requirements and the criteria of leading pharmacopoeias (USP, EP, BP, etc.).
Storage & Transportation
- Store in the original, tightly closed container in a dry place, protected from light, at a temperature not exceeding +25 °C.
- Protect from moisture (the product is highly hygroscopic).
- Transportation can be carried out by all types of covered transport, strictly observing the regulations for temperature-sensitive cargo.
- Shelf Life: 3 years from the date of manufacture (provided that container tightness is maintained).
Technical Specifications
Appearance
White or almost white amorphous powder, hygroscopic
Solubility
Freely soluble in water, practically insoluble in alcohol and ether
Anticoagulant Activity
Not less than 150 IU/mg (calculated on the dried substance)
pH (1% aqueous solution)
5.5 – 8.0
Loss on Drying
Not more than 8.0%
Residual Solvents
Meets pharmacopoeia requirements
Supply info
- Double polyethylene bags enclosed within airtight plastic canisters or aluminum drums of 0.5 kg / 1 kg / 5 kg (tailored for pharmaceutical manufacturing).
- Customized packaging options are available upon agreement with the customer.