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Pharmaceutical Chemistry
Ligustrazine Hydrochloride
Formula:
C8H12N2.ClH
GOST/CAS:
CAS 76494-51-4
Ligustrazine Hydrochloride (tetramethylpyrazine salt) is a highly effective bioactive alkaloid, originally isolated from the medicinal plant Ligusticum chuanxiong and currently produced via advanced organic synthesis. The product is a white to slightly yellowish crystalline powder with excellent water solubility. Due to its unique vasodilatory, antioxidant, and antiplatelet properties, ligustrazine serves as an indispensable raw material for the manufacturing of modern pharmaceuticals, specialized dietary supplements, and sports nutrition.
Applications
Pharmaceutical Manufacturing: Acts as the primary active pharmaceutical ingredient (API) in formulations designed to improve blood microcirculation, treat and prevent ischemic stroke, coronary heart disease, and cerebrovascular disorders.
Sports Nutrition & Dietary Supplements: Utilized as a key ingredient in pre-workout complexes and "pumping" formulations (to enhance muscle blood flow), as well as in cardiovascular support supplements for high-intensity training.
Cosmeceuticals & Anti-Hair Loss Products: Incorporated into scalp tonics and hair serums to stimulate localized blood circulation, enhance hair follicle nourishment, and accelerate hair growth.
Research & Development (R&D): Widely used in laboratory research to study mechanisms involved in combating cellular apoptosis, inflammation, and oxidative stress.
Key Advantages
High Bioavailability & Solubility: The hydrochloride form ensures rapid dissolution in liquid mediums, guaranteeing fast absorption rates and predictable efficacy in the final product.
Comprehensive Therapeutic Effect: Combines the properties of a potent vasodilator (blood vessel relaxant), an antiplatelet agent (prevents thrombus formation), and a powerful antioxidant that protects cells from oxidative damage.
Cost Efficiency & Raw Material Purity: A high concentration of the active substance (not less than 98–99%) minimizes purification costs during manufacturing and allows for precise dosing in complex multi-component blends.
Safety & Composition Stability: The synthesized product is strictly standardized, free from foreign plant allergens or heavy metals, and remains highly stable when proper storage conditions are met.
Storage & Transportation
- Store in dry, clean, cool warehouse environments in the tightly closed original packaging, protected from light, and away from heat sources.
- Recommended storage temperature:+2°C to+8°C (for long-term storage) or at room temperature not exceeding+25°C (in airtight containers without oxygen exposure).
- Avoid contact with strong oxidizers, moisture, and acids, which may degrade product quality.
- Transportation is permitted by all types of covered transport while maintaining the required temperature control. The material is not classified as dangerous goods (ADR/transport regulations). Shelf life is 2 years from the date of manufacture.
Technical Specifications
Appearance
White or almost white crystalline powder with a faint characteristic odor
Assay / Purity (on dry basis)
not less than 98.0% – 100.0% (by HPLC)
Loss on Drying / Moisture
no more than 1.0%
Melting Point
83.0°C – 87.0°C
pH (1% aqueous solution)
4.5 – 6.5
Heavy Metals
no more than 10 ppm
Supply info
- Plastic or dark glass bottles (for laboratory and small wholesale lots): 50 g / 100 g / 500 g.
- Sealed aluminum foil bags or fiber drums with double polyethylene inner liners (for industrial manufacturing): 1 kg / 5 kg / 25 kg.