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Pharmaceutical Chemistry
Pentoxifylline
Formula:
C13H18N4O3
GOST/CAS:
CAS 6493-05-6
Pentoxifylline is a highly effective xanthine-derived hemorheologic agent and angioprotector. It improves peripheral microcirculation and blood rheology (fluidity) by inhibiting blood platelet and erythrocyte aggregation, increasing red blood cell flexibility, and reducing blood viscosity. The product is a white or almost white crystalline powder that is freely soluble in water. Due to its unique vasodilating properties, Pentoxifylline is an indispensable active pharmaceutical ingredient (API) for manufacturing a wide range of medications in the modern pharmaceutical industry.
Applications
Manufacture of Finished Dosage Forms (FDF): Used as a primary active pharmaceutical ingredient (API) for the production of sustained-release tablets, capsules, as well as solutions for injections and infusions.
Angiology & Cardiology: Included in complex therapies for peripheral circulatory disorders (such as intermittent claudication, Raynaud's disease), diabetic angiopathy, and ischemic conditions.
Neurology: Used in the formulation of drugs targeted at treating cerebrovascular circulatory disorders (ischemic stroke, cerebral arteriosclerosis, and circulatory encephalopathy).
Ophthalmology & Otolaryngology: Utilized in manufacturing medications for treating ocular vascular pathologies (acute and chronic retinal circulatory insufficiency) and inner ear dysfunctions.
Key Advantages
High Purity Grade: Fully complies with leading international pharmacopoeia standards (Ph.Eur., USP, BP), ensuring the safety, efficacy, and stability of the finished drug products.
Effective Microcirculation Improvement: Provides pronounced angioprotective action, lowering blood viscosity and enhancing tissue oxygenation without causing significant systemic vasodilation adverse effects.
Process Versatility: Excellent physical and chemical powder properties make it ideal for both wet granulation and direct compression tablet manufacturing processes.
Stability & Safety: The substance exhibits high chemical stability under recommended storage conditions, does not form toxic impurities, and behaves predictably throughout technological cycles.
Storage & Transportation
- Store in dry, clean, light-protected warehouses in tightly closed original packaging, out of reach of children, at a temperature not exceeding 25 °C.
- Protect from moisture and direct sunlight to prevent degradation of the active ingredient.
- Transport is permitted by all modes of covered transport in accordance with the freight regulations applicable to each type of transport. The material is not classified as dangerous goods (exempt from ADR classification when stored and handled properly).
- Shelf Life: 3 to 5 years from the date of manufacture (depending on the manufacturer).
Technical Specifications
Appearance
White or almost white crystalline, odorless powder
Assay (On dried basis)
99.0% – 101.0%
Melting Point
104.0 °C – 107.0 °C
Loss on Drying
Not more than 0.5%
Sulfated Ash
Not more than 0.1%
Heavy Metals
Not more than 10 ppm
Solubility
Soluble in water, freely soluble in chloroform and methanol, sparingly soluble in ethanol.
Supply info
- Fiber or plastic drums with a double polyethylene inner liner at 25 kg net weight.
- Customized smaller packaging in hermetic bags is available upon request for Research & Development (R&D) purposes.