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Pharmaceutical Chemistry
Hydroxyethyl Starch (HES 130/0.4)
Formula:
C22H44O17
GOST/CAS:
CAS 9005-27-0
Hydroxyethyl Starch (HES 130/0.4) is a highly purified, modified polymer compound derived from the partial hydrolysis of waxy maize starch followed by hydroxyethylation. Featuring a strictly controlled molecular weight and substitution degree, it is an indispensable component in the pharmaceutical industry as an active substance for plasma-substituting and volume-expanding solutions. The product is a white to slightly off-white, odorless powder that is highly soluble in water, forming stable solutions with specified viscosity.
Applications
Pharmaceutical Industry: Used as an Active Pharmaceutical Ingredient (API) for the manufacturing of infusion plasma-substituting and volemic solutions. Effectively restores circulating blood volume (CBV) deficits.
Medicine and Biotechnology: Serves as a cryoprotectant for freezing and long-term storage of blood components, cell cultures, and biological tissues, preventing the destruction of cell membranes.
Dosage Form Manufacturing: Acts as an excipient, binding agent, and stabilizer in tablet pressing, encapsulation, and the development of controlled-release drug delivery systems.
Cosmeceuticals and Speciality Chemistry: Can be used as a viscosity modifier, film-former, and water-retaining agent in premium cosmetic formulations and medical gels.
Key Advantages
Optimal Volemic Effect: With a molecular weight of 130,000 Daltons and a molar substitution of 0.4, the product ensures prolonged circulation within the vascular bed without excessive tissue accumulation.
High Purity Grade: Fully complies with strict international pharmacopoeia standards (EP, USP); free from foreign impurities, toxic reagent residues, and pyrogens.
Stability and Solubility: Dissolves rapidly and completely in aqueous media (including saline), forming clear, thermally stable solutions that are highly resistant to sterilization.
Biocompatibility and Safety: Exhibits minimal impact on the hemostasis system and renal function compared to older HES generations (e.g., 200/0.5 or 450/0.7), and is fully metabolized by alpha-amylase.
Storage & Transportation
- Store in dry, clean, light-protected, and well-ventilated warehouses in the manufacturer's tightly sealed original packaging.
- Recommended storage temperature: between +5°C and +25°C. Avoid sudden temperature fluctuations to prevent moisture condensation.
- Protect from direct sunlight, heat sources, and moisture (the product is highly hygroscopic).
- Transportation is carried out by all types of covered transport in compliance with standard freight regulations. The substance is non-hazardous and does not fall under ADR/RID classifications.
- Shelf Life: 3 years from the date of manufacture.
Technical Specifications
Appearance
White or almost white amorphous powder, odorless
Molecular Weight
110,000 – 150,000 g/mol
Molar Substitution Degree
0.38 – 0.45
Assay (Core Substance)
≥ 98.5%
pH (approx. 10% aqueous solution)
5.0 – 7.0
Loss on Drying
≤ 5.0%
Supply info
- Specialized multi-layer paper bags with a hermetic internal polyethylene liner (25 kg net).
- Pharmaceutical fiber drums for sterile production environments (25 kg / 50 kg).
- Custom B2B packaging and bulk shipments are available upon agreement to match specific manufacturing requirements.