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Pharmaceutical Chemistry
Mometasone Furoate
Formula:
C27H30O6Cl2
GOST/CAS:
CAS 83919-23-7
Mometasone Furoate is a highly potent synthetic glucocorticosteroid (GCS) for topical and local administration, exhibiting pronounced anti-inflammatory, antipruritic, and anti-allergic properties. The product comes as a white or almost white crystalline powder. Combining excellent local efficacy with exceptionally low systemic absorption, Mometasone Furoate serves as an indispensable Active Pharmaceutical Ingredient (API) for formulating modern, safe, and reliable hormonal medications in the pharmaceutical industry.
Applications
Nasal Spray Production: Utilized as the core active ingredient in metered-dose nasal sprays indicated for the treatment and prophylaxis of seasonal and perennial allergic rhinitis, acute rhinosinusitis, and nasal polyposis.
Topical Dermatological Products: Formulated as the active substance in creams, ointments, and lotions developed to treat psoriasis, atopic dermatitis, eczema, and other corticosteroid-responsive dermatoses.
Pulmonology (Inhalation Products): Integrated into dry powder inhalers (DPIs) or metered-dose inhalers (MDIs) for the maintenance treatment of asthma and Chronic Obstructive Pulmonary Disease (COPD).
Key Advantages
High Local Efficacy: Rapidly suppresses inflammatory responses, effectively relieving edema, itching, and localized allergic reactions.
Minimal Systemic Exposure: Features an extremely low systemic bioavailability (less than 1%) upon topical application, significantly minimizing the risk of systemic side effects typical of general corticosteroids.
Prolonged Therapeutic Action: The specific physico-chemical profile of the substance ensures a sustained release and retention at the inflammation site, enabling convenient once-daily dosing regimens for finished products.
Exceptional Purity Profile: Strictly complies with leading international quality standards (EP/USP/BP), free from heavy impurities, which guarantees the long-term stability of the final drug formulations.
Storage & Transportation
- Store in dry, clean, and cool warehouse environments in tightly sealed original packaging (double polyethylene bag inside a protective fiber drum). Keep protected from light at temperatures not exceeding +25°C.
- Avoid direct exposure to sunlight, moisture, and heat sources. Keep away from strong oxidizing agents.
- Transportation is permitted via all types of covered transport in strict compliance with the cargo regulations applicable to each transit mode. Handle with care to prevent any container damage.
- Shelf Life: 3 to 5 years from the manufacturing date (depending on the specific manufacturer's retest period), provided the original seal integrity is maintained.
Technical Specifications
Appearance
White or almost white crystalline powder, odorless
Assay (Main Substance)
98.0% – 102.0% (on the dried basis)
Solubility
Practically insoluble in water, sparingly soluble in ethanol, freely soluble in chloroform and methylene chloride
Melting Point
Approx. 218°C – 220°C (with decomposition)
Specific Optical Rotation
+55° to +61° (as a 1% solution in dioxan)
Loss on Drying
Not more than 0.5%
Sulfated Ash
Not more than 0.1%
Supply info
- Standard pharmaceutical fiber drums with double plastic inner liners available in 1 kg, 5 kg, 10 kg, and 25 kg capacities.
- Customized small-scale packaging is available upon request for R&D, laboratory testing, and pilot-scale batch production.