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Pharmaceutical Chemistry
Croscarmellose Sodium
Formula:
C8H15NaO8
GOST/CAS:
CAS 74811-65-7
Croscarmellose sodium (a high-performance superdisintegrant) is a specialized excipient used in the pharmaceutical industry to ensure the rapid disintegration of solid dosage forms (tablets and capsules). The product is a white or almost white powder featuring a unique capability for three-dimensional swelling upon contact with water. Thanks to its strong capillary effect and high-velocity moisture absorption without forming a viscous gel, croscarmellose guarantees the maximum bioavailability of active pharmaceutical ingredients (APIs).
Applications
Direct Compression Tableting: Used as a superdisintegrant in direct compression processes. It provides instantaneous disruption of the tablet matrix in liquid media, accelerating the dissolution rate of active ingredients.
Wet and Dry Granulation: Incorporated both intra- and extra-granularly to create a combined disintegrating action, maintaining the perfect balance between tablet hardness and disintegration time.
Encapsulated Dosage Forms: Applied in filling hard gelatin and vegetable capsules to prevent caking of the powder mass and to speed up the dissolution of the capsule shell in gastric juice.
Nutraceuticals and Dietary Supplements: Actively included in formulations of vitamin-mineral complexes and supplements to improve the solubility of poorly soluble herbal extracts and minerals.
Key Advantages
Exceptional Disintegrating Power: Exhibits a "sponge" effect — rapidly absorbing moisture and expanding several times its original volume, effectively breaking the tablet apart from within without compromising its mechanical hardness during compression.
No Gel Formation: Unlike standard sodium carboxymethylcellulose, its cross-linked structure prevents the formation of a sticky hydrogel barrier that could otherwise slow down drug diffusion.
Versatility and Stability: Retains its properties across a wide pH range of the gastrointestinal tract and shows excellent compatibility with all major types of fillers (lactose, MCC, calcium phosphate) and active substances.
High Purity and Safety: Fully biocompatible, non-toxic, and hypoallergenic material. Complies with the strict requirements of leading global pharmacopoeias (USP/NF, Ph. Eur., BP).
Storage & Transportation
- Store in dry, cool, and well-ventilated warehouses in tightly closed original packaging, away from heat sources.
- The product is highly hygroscopic! Avoid direct moisture exposure and storage in conditions of high air humidity.
- Transportation is permitted by all types of covered transport in compliance with standard temperature regulations. The product is classified as non-hazardous for transport.
- Shelf life: 3 years from the date of manufacture.
Technical Specifications
Appearance
White or almost white powder, odorless
Solubility
Practically insoluble in water, acetone, ethanol, and toluene; swells strongly
Assay (Sodium Content)
≥ 99.5%
Degree of Substitution
0.60 - 0.85
pH (1% aqueous suspension)
5.0 - 7.0
Loss on Drying
≤ 10.0%
Supply info
- Industrial multi-layer kraft bags with a hermetic polyethylene inner liner (25 kg net).
- Palletized shipment wrapped in stretch film is available for large wholesale batches.