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Pharmaceutical Chemistry
Nimodipine
Formula:
C21H26N2O7
GOST/CAS:
66085-59-4
Nimodipine (a highly effective L-type "slow" calcium channel blocker belonging to the dihydropyridine derivative group) is a specialized pharmaceutical component (Active Pharmaceutical Ingredient) that acts as a key agent for cerebral vasodilation and the improvement of cerebral blood circulation. The product is a white to light yellow crystalline powder, practically insoluble in water but readily soluble in organic solvents. Due to its high lipophilicity, nimodipine easily crosses the blood-brain barrier and selectively targets cerebral arterioles. This makes it an indispensable raw material in the manufacturing of finished dosage forms (tablets and infusion solutions) for neurology and cardiology.
Applications
Infusion Solution Manufacturing: Used as a base component for formulation of sterile intravenous solutions. Provides emergency therapy for acute cerebrovascular disorders and hemorrhagic strokes.
Oral Dosage Form Production: Applied as an active substance for manufacturing tablets and capsules. Designed for routine course treatment to prevent and treat ischemic neurological disorders.
Geriatric Pharmacology: Incorporated into drug formulations aimed at improving memory, concentration, and cognitive functions in elderly patients suffering from cerebrovascular insufficiency.
Research & Development: Utilized in laboratory practices and R&D centers for the development of innovative combination drugs with neuroprotective properties.
Key Advantages
High Selectivity: Selectively blocks calcium channels in the smooth muscles of cerebral blood vessels, exerting virtually no effect on systemic blood pressure or the myocardium.
Stability and Chemical Purity: The substance possesses stable physicochemical properties and a high degree of purity, minimizing the presence of secondary impurities in the finished medicinal product.
Pronounced Neuroprotective Effect: Effectively protects neurons from hypoxia and calcium ion overload, preventing the development of vasospasms and stabilizing the functional state of brain cells.
Compliance with Standards (Ph. Eur. / USP): The product is manufactured in strict compliance with international GMP requirements, guaranteeing safety, non-toxicity (within therapeutic doses), and consistent quality.
Storage & Transportation
- Store in dry, cool, and well-ventilated warehouse premises in tightly closed original packaging, away from heat sources.
- Special Conditions: The product is extremely light-sensitive. Store exclusively in a dark place protected from light (in light-proof containers).
- Recommended temperature range: +15°C to $+25°C (do not allow overheating).
- Transportation is permitted by all types of covered transport while strictly adhering to the temperature regime and maintaining mandatory protection from direct sunlight. The material is not classified as a dangerous good (UN Class 9 is absent). Shelf life — 3 years from the date of manufacture.
Technical Specifications
Appearance
White to pale yellow crystalline powder. Light-sensitive.
Molecular Weight
418.44 g/mol
Assay (On Dried Basis)
≥ 99.0%
Melting Point
124.0°C – 128.0°C
Loss on Drying
≤ 0.5%
Residual Solvents
Meets the requirements of ICH standards
Supply info
- Double polyethylene light-shielding bags, hermetically sealed inside aluminum bags.
- Fibre or plastic drums (cans) containing 5 kg, 10 kg, and 25 kg (optimized for pharmaceutical manufacturing scale).
- Customized batch configurations are available based on client requirements (provided with a full documentation package: CoA, DMF, GMP).